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The tobacco company RJ Reynolds patented nicotine salts to increase the nicotine content of products but prevent what would otherwise cause more intense throat irritation if it were freebase nicotine of such concentration

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Int J Environ Res Public Health 10 , 51465162, (2013)

Longitudinal studies have shown that adolescents who begin with e-cigarettes are significantly more likely to transition to combustible tobacco products, a progression that reopens pathways to the very cancer risks that decades of tobacco control sought to close